abstract：:Mammary epithelia and the epidermis share a common embryologic origin. Like resident epidermal T cells (ETC), a significant number of murine mammary gland T cells (MTC) express Vgamma5-T-cell receptors (TCR). MTC were assessed to see if they express the same invariant Vgamma5/Vdelta1-TCRs as those of ETC. MTC-derived ...

journal_title：Molecular immunology

authors： Reardon C,Born WK,O'Brien RL

更新日期：2006-03-01 00:00:00

abstract：:Triptolide has been used extensively in China for the treatment of autoimmune diseases and tumor for many centuries. Nevertheless, little is known about its exact immunosuppressive and anti-inflammatory properties. Increasing recognition of the importance of renal tubular epithelial cells (TECs) in renal diseases rais...

journal_title：Molecular immunology

authors： Chen Y,Zhang J,Li J,Zhao T,Zou L,Tang Y,Zhang X,Wu Y

更新日期：2006-03-01 00:00:00

abstract：:In periodontal disease, IgG1 and IgA1 antibodies produced in situ deposit on antigens in the affected tissues. Thus, there is an interest in the effect of co-deposited IgA1 antibodies on complement activation by IgG1-immune complexes. In the present study, we first analyzed the effect of IgA1-immune complexes on compl...

journal_title：Molecular immunology

authors： Boackle RJ,Nguyen QL,Leite RS,Yang X,Vesely J

更新日期：2006-02-01 00:00:00

abstract：:Properly regulated mitogen-activated protein (MAP) kinase activity is critical for normal thymocyte development. MAP kinases are activated by phosphorylation of tyrosine and threonine, and dual specificity phosphatases (DUSPs) can inactivate MAP kinases by dephosphorylating both tyrosine and threonine. However, a role...

journal_title：Molecular immunology

authors： Tanzola MB,Kersh GJ

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Individuals genetically deficient of properdin are more susceptible to meningococcal disease. Likewise low concentration or decreased biological activity of mannose-binding lectin (MBL) is associated with higher incidence of bacterial infections during childhood. In this study we report our findings in a Dan...

journal_title：Molecular immunology

authors： Bathum L,Hansen H,Teisner B,Koch C,Garred P,Rasmussen K,Wang P

更新日期：2006-02-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are important components of the host's innate immune response against microbial invasion. The cysteine-rich AMPs such as defensin and hepcidin have been extensively studied, but the recently identified cysteine-rich liver-expressed antimicrobial peptide 2 (LEAP-2) has been characterized f...

journal_title：Molecular immunology

authors： Bao B,Peatman E,Xu P,Li P,Zeng H,He C,Liu Z

更新日期：2006-02-01 00:00:00

abstract：:Despite the fact that receptors for complement on T-cells have been described many years ago the function remains unclear as is the role of complement in the T-cell response. In this review we will evaluate how the accumulated wisdom concur with the current concepts of the adaptive T-cell response. ...

journal_title：Molecular immunology

authors： Wagner C,Hänsch GM

更新日期：2006-01-01 00:00:00

abstract：:Mannan-binding lectin (MBL) is a plasma protein of the innate immune system with the ability to initiate antimicrobial and inflammatory actions. MBL deficiency is common. More than 10% of the general population may, depending on definition, be classified as MBL deficient, underlining the redundancy of the immune syste...

journal_title：Molecular immunology

authors： Thiel S,Frederiksen PD,Jensenius JC

更新日期：2006-01-01 00:00:00

abstract：:Pathogenic micro-organisms employ a broad range of strategies to survive in and to persistently infect the human host. Far from being completely understood by which highly sophisticated means invading pathogens overcome the host's destructive immune defence, there is a growing body of evidence on particular mechanisms...

journal_title：Molecular immunology

authors： Kraiczy P,Würzner R

更新日期：2006-01-01 00:00:00

abstract：:To test the fate of developing B cells with autoreactive receptor components, we studied mice homozygous for a knock-in transgene coding the VH domain of an IgM ssDNA-binding antibody. The transgene has unmutated C57 BL/6 V gene segments. Homozygous knock-in mice developed normal numbers of spleen and bone marrow B ce...

journal_title：Molecular immunology

authors： Li J,Geissal ED,Li W,Stollar BD

更新日期：2005-08-01 00:00:00

abstract：:Activation-induced cell death (AICD) in T lymphocytes depends on the expression of Fas-ligand, which triggers the apoptotic process after binding to its receptor Fas. This leads to the activation of cysteine proteases of the caspase family and especially of caspase-3, a critical effector protein during AICD. We have p...

journal_title：Molecular immunology

authors： Sabbagh L,Bourbonnière M,Sékaly RP,Cohen LY

更新日期：2005-07-01 00:00:00

abstract：:Rainbow trout (Oncorhynchus mykiss) cells of a monocyte-macrophage lineage (rtMOCs) were used to characterize the ability of the trout innate immune system to recognize and respond to different pathogen associated molecular pattern (PAMP) bearing substances. Compared to what has been reported for mammalian macrophages...

journal_title：Molecular immunology

authors： Iliev DB,Liarte CQ,MacKenzie S,Goetz FW

更新日期：2005-06-01 00:00:00

abstract：:The mucosal surface of the gastrointestinal tract represents a major entry point and ecological niche for many microbes. It forms an important immune barrier, absorbing nutrients, whilst preventing invasion by organisms. Of the extra-ordinarily diverse species that comprise the microbial world, relatively few organism...

journal_title：Molecular immunology

authors： Dommett R,Zilbauer M,George JT,Bajaj-Elliott M

更新日期：2005-05-01 00:00:00

abstract：:Of the antioxidant/prooxidant mechanisms mediating the regulation of inflammatory mediators, particularly cytokines, oxidative stress-related pathways remain a cornerstone. It is conspicuous that there is a strong association between free radical accumulation (ROS/RNS; oxidative stress) and the evolution of inflammati...

journal_title：Molecular immunology

authors： Haddad JJ,Harb HL

更新日期：2005-05-01 00:00:00

abstract：:Immunoglobulins (Ig) require correct folding and assembly of both heavy (H) and light (L) chains to form a functional H2L2 dimer that is secreted from plasma cells. This process is dependent upon the endoplasmic reticulum (ER) chaperone BiP, which targets improperly, folded or assembled Ig molecules for degradation. W...

journal_title：Molecular immunology

authors： McLean GR,Torres M,Trotter B,Noseda M,Bryson S,Pai EF,Schrader JW,Casadevall A

更新日期：2005-05-01 00:00:00

abstract：:UL16 binding proteins (ULBPs) are ligands for the NK cell activating receptor NKG2D. A cDNA encoding a porcine ULBP-like protein (PULBP) was cloned and the predicted amino acid sequence exhibited 35-52% identity to human ULBPs. Southern blot analysis suggested that there is only one ULBP-like gene in the pig genome. T...

journal_title：Molecular immunology

authors： García-Borges CN,Phanavanh B,Saraswati S,Dennis RA,Crew MD

更新日期：2005-04-01 00:00:00

abstract：:Immunoglobulin heavy chain (Igh) locus rearrangements are controlled in part by an approximately 30 b complex 3' regulatory region located 3' of C alpha: this region contains several enhancers. We report here the comparison of the genomic sequences of the 3' regulatory region and further downstream sequences from mous...

journal_title：Molecular immunology

authors： Sepulveda MA,Garrett FE,Price-Whelan A,Birshtein BK

更新日期：2005-03-01 00:00:00

abstract：:The disialoganglioside GalAcbeta1-4(NeuAcalpha2-8NeuAcalpha2-3)Galbeta1-4Glcbeta1-1Cer (GD2) is expressed on various tumors, including neuroblastoma, and was defined as a relevant tumor antigen. The monoclonal anti-GD2 antibody 14.18 is widely used for diagnostic purposes in neuroblastoma, and in its mouse/human chime...

journal_title：Molecular immunology

authors： Förster-Waldl E,Riemer AB,Dehof AK,Neumann D,Brämswig K,Boltz-Nitulescu G,Pehamberger H,Zielinski CC,Scheiner O,Pollak A,Lode H,Jensen-Jarolim E

更新日期：2005-02-01 00:00:00

abstract：:Natural killer cells fail to lyse target cells expressing sufficient levels of self MHC class I molecules, providing one mechanism to secure self tolerance. Inhibition of lysis is mediated by inhibitory receptors expressed by NK cells, such as the murine Ly49 receptors, human KIR receptors and CD94/NKG2A, expressed by...

journal_title：Molecular immunology

authors： Salmon-Divon M,Höglund P,Johansson MH,Johansson S,Mehr R

更新日期：2005-02-01 00:00:00

abstract：:The capability of NK lymphocytes to kill tumor cells depends on different receptors/ligands interactions. In order to identify the cellular ligands recognized by "orphan" triggering receptors, mice were immunized with NK susceptible target cells. mAbs were selected that inhibited NK cytotoxicity and recognized two dif...

journal_title：Molecular immunology

authors： Pende D,Bottino C,Castriconi R,Cantoni C,Marcenaro S,Rivera P,Spaggiari GM,Dondero A,Carnemolla B,Reymond N,Mingari MC,Lopez M,Moretta L,Moretta A

更新日期：2005-02-01 00:00:00

abstract：:Recent reports demonstrate that natural killer (NK) cells and dendritic cells (DC) support each other's activity in a positive feedback. We observed that activated NK cells induce the maturation of DCs into stable type-1 polarized DCs (DC1), characterized by up to 100-fold enhanced ability to produce IL-12p70 in respo...

journal_title：Molecular immunology

authors： Kalinski P,Giermasz A,Nakamura Y,Basse P,Storkus WJ,Kirkwood JM,Mailliard RB

更新日期：2005-02-01 00:00:00

abstract：:Dendritic cells (DC) survey epithelial or mucosal surfaces for antigens, take them up via their endocytic or phagocytic receptors, process the captured antigens and migrate to the lymphatic tissues. In the draining lymph nodes they present the immunogenic peptides to T cells thereby inducing antigen-specific immune re...

journal_title：Molecular immunology

authors： Wilflingseder D,Banki Z,Dierich MP,Stoiber H

更新日期：2005-02-01 00:00:00

abstract：:The dynamics of human antigen-specific immunoglobulin (Ig) responses in early life are not well characterized. We have previously observed an inverse relationship between allergen-specific Ig concentration and allergen-Ig-binding affinity in allergen-sensitive atopic adults, suggesting a possible feedback relationship...

journal_title：Molecular immunology

authors： Jackola DR,Liebeler CL,Lin CY,Chiu YK,Blumenthal MN,Rosenberg A

更新日期：2005-01-01 00:00:00

abstract：:We investigated the structure and expression of immunoglobulin genes in the pufferfish, Takifugu rubripes, a highly prized and economically important fish species. The cDNA fragment that partially encodes the constant region of the IgM heavy chain was isolated in these animals by RACE using degenerate primers after wh...

journal_title：Molecular immunology

authors： Saha NR,Suetake H,Suzuki Y

更新日期：2005-01-01 00:00:00

abstract：:The complement (C) inflammatory cascade is part of the phylogenetically ancient innate immune response and is crucial to our natural ability to ward off infection. It has three critical physiologic activities: (i) defending against microbial infections by triggering the generation of a membranolytic complex (C5b9 comp...

journal_title：Molecular immunology

authors： Gasque P

更新日期：2004-11-01 00:00:00

abstract：:Antigen-stimulated B lymphocytes undergo genetic and phenotypic changes in germinal centers (GCs), including affinity maturation of immunoglobulin (Ig) genes and Ig heavy chain isotype switching. Expression of the Germinal Center Expressed Transcript (GCET) gene is up-regulated in murine GC B cells. The human homolog ...

journal_title：Molecular immunology

authors： Steinke JW,Hodsdon W,Parenti S,Ostraat R,Lutz R,Borish L,Hagman J

更新日期：2004-11-01 00:00:00

abstract：:Interleukin-12 (IL-12) is a heterodimeric cytokine produced by macrophages in response to intracellular pathogens and provides an obligatory signal for the differentiation of T-helper-1 cells. p300 is an important histone acetyltransferase (HAT) and has been implicated in the regulation of gene expression. Whether p30...

journal_title：Molecular immunology

authors： Sun H,Lu J,Wei L,Wang X,Xu X,Dong M,Huang B

更新日期：2004-11-01 00:00:00

abstract：:It has been developed an HIV type 1 transgenic rat model (HIV-1 Tg Rat) which contains a gag-pol-deleted HIV-1 provirus regulated by the viral LTR promoter. Although it harbors a non infectious provirus, efficient viral expression occurs in different tissues and disease manifestations as well as immune-response altera...

journal_title：Molecular immunology

authors： Mazzucchelli R,Amadio M,Curreli S,Denaro F,Bemis K,Reid W,Bryant J,Riva A,Galli M,Zella D

更新日期：2004-08-01 00:00:00

abstract：:We recently identified IgE-binding epitopes of bovine serum albumin (BSA), the major beef allergen, and found that the major epitope structure contains an EXXV motif. Here we report hypoallergenic analogue peptides of BSA that preserve T cell reactivity to retain the capacity to induce immunotolerance. Substitution of...

journal_title：Molecular immunology

authors： Tanabe S,Shibata R,Nishimura T

更新日期：2004-07-01 00:00:00

abstract：:Clonal idiotypic immunoglobulins of follicular lymphomas can be isolated by somatic fusion procedures. Idiotypic IgMs (Id-IgM) were isolated from two patients and used to immunise a strain of mice, deficient in mouse antibody production and engineered with yeast artificial chromosomes (YAC) containing fragments of the...

journal_title：Molecular immunology

authors： Suárez E,Yáñez R,Barrios Y,Díaz-Espada F

更新日期：2004-07-01 00:00:00

abstract：:The structural and functional integrity of the cell is largely maintained by protein-protein interactions. Recently, we demonstrated that multiple antigenic peptides (MAPs) constructed from 60 kDa Ro sequence could be used to show intramolecular and intermolecular protein-protein interaction within the 60 kDa Ro ribon...

journal_title：Molecular immunology

authors： Scofield RH,Kurien BT,Gross JK,Reed NB,Taylor AK,Dominguez N,Mehta P,Guthridge JM,Bachmann M

更新日期：2004-07-01 00:00:00

abstract：:In immune cells, Src-family kinases have been implicated as critical regulators of a large number of intracellular signaling pathways. Studies of gene knockout mice lacking various family members have both confirmed the requirement for these kinases in some pathways and provided surprising insight into their roles in ...

journal_title：Molecular immunology

authors： Lowell CA

更新日期：2004-07-01 00:00:00

abstract：:Quiescent T lymphocytes reorganize the actin cytoskeleton subsequent to interaction with antigen presenting cells bearing the appropriate peptide antigen. Although both biochemical and genetic evidence indicate that T cell receptor-dependent cytoskeletal reorganization is critical to T cell activation, the mechanisms ...

journal_title：Molecular immunology

authors： Lu Q,Liu X,Trama J,Roti MA,Go WY,Ho SN

更新日期：2004-06-01 00:00:00

abstract：:The alternative pathway of complement is receiving increasing attention as a therapeutic target because of recent findings in several animal models that support its essential role in tissue injury and disease pathogenesis. Although the contribution of alternative pathway activation to serum complement activation in vi...

journal_title：Molecular immunology

authors： Holers VM,Thurman JM

更新日期：2004-06-01 00:00:00

abstract：:Superantigens, like staphylococcal enterotoxin A (SEA), induce a strong proliferative response followed by clonal deletion of a substantial portion of defined V(beta) T-cells. The remaining cells display in vitro anergy. Anergy is a major mechanism to ensure antigen-specific tolerance in T-lymphocyte in the adult. Co-...

journal_title：Molecular immunology

authors： Xu GL,Zhu XH,Guo B,Wu YZ

更新日期：2004-05-01 00:00:00

abstract：:The 3-D complex structures of extracellular domain of human CD16 (FcgammaRIII) and hIgG1 or B88-9 were obtained by means of computer-guided molecular modeling, respectively. The binding epitopes were predicted and binding energy was calculated theoretically. The epitopes of human CD16 interacted with hIgG1 and B88-9 w...

journal_title：Molecular immunology

authors： Feng J,Xie Z,Yu M,Guo N,Shen B

更新日期：2004-05-01 00:00:00

abstract：:In the present study, we report the activation of murine peritoneal macrophages in vitro on irradiation with sublethal dose of UVB (50 mJ/cm(2)). The activation involves enhanced expression of CD18 molecule and production of nitric oxide (NO), tumor necrosis factor (TNF-alpha) and interleukin-1 (IL-1). Production of N...

journal_title：Molecular immunology

authors： Sethi G,Sodhi A

更新日期：2004-04-01 00:00:00

abstract：:Low molecular weight hemorrhagins were purified from crude Bothrops atrox snake venom by gel filtration followed by ionic strength chromatography. The protein fractions obtained, designated HI-1 to HI-8, contained proteins with molecular masses lower than 30 kDa. HI-5, the most representative among of these fractions,...

journal_title：Molecular immunology

authors： Rodrigues FG,Petretski JH,Kanashiro MM,Lemos L,da Silva WD,Kipnis TL

更新日期：2004-03-01 00:00:00

abstract：:The O-antigen of the gram negative bacteria Brucella is composed of an homopolymer of 4,6-dideoxy-4-formamido-alpha-D-mannopyranosyl (or perosamine). Several mAb interact specifically with only the O-antigen of certain Brucella species. Although, many studies show that this specific recognition results mainly from the...

journal_title：Molecular immunology

authors： Laurent TC,Mertens P,Dierick JF,Letesson JJ,Lambert C,De Bolle X

更新日期：2004-03-01 00:00:00

abstract：:The paper evaluates the role of the concept of degeneracy in current immunology. The historical background of the notion is considered, as well as that of related concepts like 'cross-reactivity' and 'promiscuity'. A distinction is made between degeneracy, as a property of a system and promiscuity, as a property of an...

journal_title：Molecular immunology

authors： Parnes O

更新日期：2004-02-01 00:00:00